CAS: 65405-84-7
Cetonal™ is a brand name for Ketoprofen lysine salt, a non-steroidal anti-inflammatory drug (NSAID). It acts by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are key mediators of pain, inflammation, and fever. The lysine salt form enhances the solubility and bioavailability of ketoprofen, leading to a faster absorption and quicker onset of action compared to ketoprofen free acid.
It is primarily used for the symptomatic treatment of various pain and inflammatory conditions. This includes mild to moderate pain, acute musculoskeletal pain, post-operative pain, dental pain, dysmenorrhea (menstrual pain), and the symptomatic treatment of inflammatory rheumatic diseases and other inflammatory conditions.
As a pharmaceutical agent, Cetonal™ (Ketoprofen lysine salt) is applied in human medicine for its analgesic (pain-relieving), anti-inflammatory, and antipyretic (fever-reducing) properties. It is available in various pharmaceutical formulations, such as oral granules, tablets, and topical gels, for systemic or local administration in the management of pain and inflammatory processes.
Common side effects include gastrointestinal disturbances (e.g., dyspepsia, nausea, abdominal pain), and there is a risk of more serious gastrointestinal events such as ulcers and bleeding. Other potential side effects include renal impairment, cardiovascular risks (e.g., increased risk of thrombotic events), and allergic reactions. Contraindications include active peptic ulcer, gastrointestinal bleeding, severe renal or hepatic impairment, severe heart failure, and hypersensitivity to NSAIDs or aspirin. It should be used with caution in the elderly, during pregnancy (especially in the third trimester), and in patients with a history of asthma or allergies.
Ketoprofen lysine salt; Ketoprofen lysinate; (RS)-2-(3-benzoylphenyl)propionic acidL-lysine salt; Lysine ketoprofen
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