CAS: 6707-60-4
Cervolide is a steroidal lactone belonging to the bufadienolide class. It is a natural product originally isolated from the venom of the toad *Bufo calamita* (now *Epidalea calamita*). Its chemical structure is C24H32O4 with a molecular weight of 384.5 g/mol. Like other bufadienolides, it is known for its cardiotonic activity through the inhibition of Na+/K+-ATPase.
Cervolide is primarily used in biochemical and pharmacological research to study its cardiotonic effects and its interaction with, and inhibition of, Na+/K+-ATPase. It serves as a tool for understanding the mechanisms of action of cardiac glycosides and related compounds in various biological systems.
Due to its cardiotonic properties and potential cytotoxic effects (shared with other bufadienolides), Cervolide may be investigated in the context of cardiovascular diseases and oncology research. It is predominantly a research chemical and does not have established direct therapeutic or industrial applications.
As a bufadienolide, Cervolide is expected to be toxic, primarily affecting cardiac function due to its strong inhibition of Na+/K+-ATPase. Exposure may lead to cardiotoxicity, including arrhythmias, and other symptoms such as nausea, vomiting, and visual disturbances. It should be handled with extreme care in a laboratory setting, using appropriate personal protective equipment (gloves, eye protection, lab coat) and ventilation. Avoid ingestion, skin contact, and inhalation.
(3beta)-314-Dihydroxybufa-42022-trienolide3beta14-Dihydroxy-bufa-42022-trien-23-olide
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